Most cases of toxoplasmosis infection show no clinical symptoms. The only way to determine whether a mother is infected or not is to check blood serum that would indicate presence or absence of parasite called Toxoplasma gondii. Basically, the body will react to any germs that enter and cause infection by forming a specific defense system.
When first infected (primary infection), the human body will form a compound protein IgM (immunoglobulin M) in reaction to the entry of aliens into the body. Compounds of this protein in a relatively short time so the body is formed directly exposed to infection. IgM antibodies will appear in the first week of infection, reaching a peak on one month, then decreased. In some individuals, IgM may remain detectable several years after primary infection. But slowly, this IgM will disappear within 1-24 months later and could arise again if the relevant re-infected.
Depending on the conditions Approximately 4 weeks after the primary infection will be formed also IgG (Immunoglobulin G), which is a repellent or immune substances. IgG is also a protein with large molecular weight. The presence of IgG indicates that the body has been established immunity. So, if the titer / positive number means the body has established immunity against the organism causing the infection. IgG Theoretically this will settle in the body. Only, the levels can go up or down depending on one's health condition. However, in most cases, IgG and IgM rising settled.
IgG and IgM positive indicate a primary infection. This needs treatment and evaluation, both the mother and baby. If IgG positive IgM negative while indicating a recent infection. If the re-examination of the results of IgM and then becomes negative, it means that the detected IgM initially non-specific.
IgG antibodies appear several weeks after IgM response will reach a maximum of 6 months later. The high can last for several years, but finally there is a decrease little by little, generate low and stable levels that may last a lifetime. Thus, mothers who were infected with toxoplasmosis in the past, his IgG titer is never zero or negative.
Allegations against TORCH infections usually are proven through blood tests to measure titer IgG, IgM, or both at once. If IgM can be detected about a week after the acute infection and persist for several weeks or months, IgG antibodies may not appear until several weeks later after the number of IgM increased.
If suspected of being infected, but in fact IgM negative, then the laboratory should be repeated 4 weeks from the first laboratory examination. It is important to ensure there is infection or not. When the re-examination of IgM remained negative, but IgG titers showed increased 4 times, the possibility of being infected is concerned. The occurrence of change in IgM titer from negative to positive, the possibility of re-infected in question middle.
Reexamination The numbers are legible on the results of laboratory examination of blood serum, whether positive or negative, is found only limited to the infectious diseases that can tertitrasi, namely due to TORCH infections. However, although the figures are obtained, the certainty of this infection remains to be proven by further investigation, such as bacterial culture and examination of amniotic fluid. Unfortunately, in Indonesia can not be done so that the diagnosis of viral culture examination of TORCH infection based solely on laboratory results are not necessarily 100 percent true. Why is that?
Therefore, the accuracy of the figures themselves once again terpulang on inspection machines used in the laboratory. That's why doctors often advise patients to do a re-examination to the laboratory examination is different because it is very likely in a laboratory different from the results in other laboratories. The difference itself can be because of the engine, can also be due to a decrease or increase in titer of IgG and IgM according to the current condition of the patient.
When the re-examination 4-6 weeks later IgG did not increase significantly or have no IgM positive value, you can draw a sigh of relief because it means you do not need to receive treatment. It would be better if re-examination was followed by IgG aviditas examination to determine whether a fetus is also infected or not. Aviditas low IgG indicates recent infection, while high IgG aviditas a sign of past immunity.
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